SUPPOSITORY INFORMATION

1) Why suppositories Make Sense

Medication comes in several different forms: pills, liquid, injection just to name three. Suppositories are another way of introducing medication into the body without the potentially harmful side effect of liver toxicity. Suppositories come in different sizes and shapes—from ovals a few milliliters in length to the size of a grain of rice. They can be round, oval or cone shaped to fit the opening they’re made for. Suppositories are covered with a gelatin like substance that melts with body heat, thus releasing a bit of the medication over time. Suppositories may not be the most comfortable medication to take, but they are effective alternatives to taking oral medication which may cause nausea/vomiting and which may not be well absorbed by the stomach and intestines. 2019 WebMD, LLC

2) Advantages of Sustained Release with Suppositories

In order for a product to be effective, it must deliver safe and effective dosages of the most bioactive form of the compounds. Medication needed for the body can be directed right to the affected part without going through the gi system and liver. More of the medication is saved to go directly where needed. With sustained release (the gelatin outer core melts slowly in response to body temperature) the medication remains viable to treat the affected body part(s) longer making the medication more effective in the healing process. https://www.nursingtimes.net/rectal-drug-administration-in-adults-22-02-2016

3) Suppositories and Synergy

What are Phospholipids? Phospholipids provide barriers in cellular membranes to protect the cell . . . Phospholipids work to provide pathways for various substances across membranes . . . Phospholipids contribute to the surface charge of membranes as well. https://sciencing.com

What are Peptides? Peptides are smaller versions of proteins, which are very beneficial for their potential anti-aging, anti-inflammatory properties. Suppositories are proven to carry peptides well. https://medicalnewstoday.com

What are Beta Cyclodextrins? Substances, aka carriers, which help to improve the stability of drugs. They are used in the manufacture of our suppositories. https://doi.org

4) Suppositories and Bio-availability

“A drug that is administered by suppository will in general have a faster onset, higher bio-availability (available to the living system, the body), faster onset of medication release, and a shorter peak. Another advantage of administering by suppository is that it tends to produce less nausea compared to the oral route and prevents any amount of the medication being lost due to vomiting. In addition suppositories bypass around two thirds of the first-pass metabolism . . . This means the drug will reach the circulatory system with significantly less alteration and in greater concentration . . . Further, medication administered by suppositories may help the patient to remain in the home rather than in an inpatient environment as would be the case if the medication were delivered intravenously . . .” https://en.m.wikipedia.org

5) Suppositories and Uptake

“The body absorbs drugs from suppositories quickly. Rhey work faster than medications you take by mouth. This is because suppositories melt inside the body and absorb directly into the bloodstream . . . the length of time it takes for a suppository to dissolve varies on a number of factors, including your body temperature, the temperature of the suppository prior to insertion, and the type of base. On average most suppositories will melt in 10-15 minutes, although it can take up to a half hour.” https://ctocrx.com

6) Suppositories and Drug Interactions

As with any combination of medications talk to your physician and pharmacist about drug interactions before starting to take either a suppository, oral, topical or IV medication. That is the safest route to follow. https://www.drugs.com

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